- Title
- The source of cell-free mitochondrial DNA in trauma and potential therapeutic strategies
- Creator
- Thurairajah, Kabilan; Briggs, Gabrielle Daisy; Balogh, Zsolt Janos
- Relation
- European Journal of Trauma and Emergency Surgery Vol. 44, Issue 3, p. 325-334
- Publisher Link
- http://dx.doi.org/10.1007/s00068-018-0954-3
- Publisher
- Springer
- Resource Type
- journal article
- Date
- 2018
- Description
- Mitochondria play a key role in the pathophysiology of post-injury inflammation. Cell-free mitochondrial DNA (cf-mtDNA) is now understood to catalyse sterile inflammation after trauma. Observations in trauma cohorts have identified high cf-mtDNA in patients with systemic inflammatory response syndrome and multiple organ failure as well as following major surgery. The source of cf-mtDNA can be various cells affected by mechanical and hypoxic injury (passive mechanism) or induced by inflammatory mechanisms (active mechanism). Multiple forms of cf-mtDNA exist; mtDNA fragments, mtDNA in microparticles/vesicles and cell-free mitochondria. Trauma to cells that are rich in mitochondria are believed to release more cf-mtDNA. This review describes the current understanding of the mechanisms of cf-mtDNA release, its systemic effects and the potential therapeutic implications related to its modification. Although current understanding is insufficient to change trauma management, focussed research goals have been identified to pave the way for monitoring and manipulation of cf-mtDNA release and effects in trauma.
- Subject
- cell-free mitochondrial DNA (mtDNA); inflammation; trauma; therapeutics
- Identifier
- http://hdl.handle.net/1959.13/1472420
- Identifier
- uon:48824
- Identifier
- ISSN:1863-9933
- Rights
- This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Language
- eng
- Full Text
- Reviewed
- Hits: 427
- Visitors: 450
- Downloads: 29
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 1017 KB | Adobe Acrobat PDF | View Details Download |